Tbio LRBA Lipopolysaccharide-responsive and beige-like anchor protein

Protein Summary

Description

May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• P50851
• Q4W5J4
• Q4W5L6
• Q8NFQ0
• Q9H2U3
• Q9H2U4

Gene Name

• LRBA

Ensembl ID

• ENST00000357115
• ENSP00000349629
• ENSG00000198589
• ENST00000510413
• ENSP00000421552

Symbol

• BGL
• CDC4L
• LBA
• BGL
• LBA
• CDC4L
• CVID8
• LAB300

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.98
protein domain	0.97
transcription factor perturbation	0.96
interacting protein	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.34   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.34   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0