Tchem ATG7 Ubiquitin-like modifier-activating enzyme ATG7

Protein Summary

Description

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• O95352
• B4E170
• E9PB95
• Q7L8L0
• Q9BWP2
• Q9UFH4

Gene Name

• ATG7

Ensembl ID

• ENST00000354449
• ENSP00000346437
• ENSG00000197548
• ENST00000354956
• ENSP00000347042
• ENST00000446450
• ENSP00000412580

Symbol

• APG7L
• GSA7
• APG7L
• APG7-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
interacting protein	1
transcription factor perturbation	0.96
transcription factor binding site profile	0.84
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ubiquitin-like Modifier-activating Enzyme Atg7

Protein / Ligase / Ubiquitin-like Modifier-activating Enzyme Atg7

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-like Modifier-activating Enzyme Atg7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.46   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 720   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.46   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0