Tclin KCNJ11 ATP-sensitive inward rectifier potassium channel 11

Protein Summary

Description

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q14654
• B4DWI4
• E9PNK0
• Q2M1H7
• Q58EX3
• Q8IW96

Gene Name

• KCNJ11

Ensembl ID

• ENST00000339994
• ENSP00000345708
• ENSG00000187486
• ENST00000528731
• ENSP00000434755

Symbol

• BIR
• HHF2
• PHHI
• IKATP
• TNDM3
• KIR6.2
• MODY13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.92
biological term	0.8
cell type or tissue	0.74
cellular component	0.74

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj11 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1636.54   (req: < 5)

Gene RIFs: 295   (req: <= 3)

Antibodies: 419   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1636.54   (req: >= 5)

Gene RIFs: 295   (req: > 3)

Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 18