Tbio HAVCR1 Hepatitis A virus cellular receptor 1

Protein Summary

Description

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• Q96D42
• O43656
• HAVcr-1

Gene Name

• HAVCR1

Ensembl ID

• ENST00000339252
• ENSP00000344844
• ENSG00000113249
• ENST00000523175
• ENSP00000427898

Symbol

• KIM1
• TIM1
• TIMD1
• TIM
• KIM1
• TIM1
• CD365
• HAVCR
• KIM-1
• TIM-1
• TIMD1
• TIMD-1
• HAVCR-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
chemical	0.7
disease	0.57
biological term	0.54
cell line	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1269.12   (req: < 5)

Gene RIFs: 219   (req: <= 3)

Antibodies: 771   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1269.12   (req: >= 5)

Gene RIFs: 219   (req: > 3)

Antibodies: 771   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0