Protein Summary
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
- ENST00000349314
- ENSP00000344577
- ENSG00000128284
- ENST00000361710
- ENSP00000355164
- ENST00000397287
- ENSP00000380456
- ENST00000397293
- ENSP00000380461
- ENST00000424878
- ENSP00000415779
- CG121
- CG12_1
- APOLIII
- apoL-III
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
tissue sample | 0.71 | ||
tissue | 0.61 | ||
gene perturbation | 0.54 | ||
PubMedID | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.75 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.75 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0