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Tbio
FXYD5
FXYD domain-containing ion transport regulator 5

Protein Summary
Description
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342879
  • ENSP00000344254
  • ENSG00000089327
  • ENST00000392217
  • ENSP00000376051
  • ENST00000392219
  • ENSP00000376053
  • ENST00000423817
  • ENSP00000393848
  • ENST00000541435
  • ENSP00000443390
  • ENST00000590686
  • ENSP00000465667

Symbol
  • DYSAD
  • IWU1
  • RIC
  • IWU1
  • KCT1
  • OIT2
  • DYSAD
  • HSPC113
  • PRO6241
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor perturbation
0.88
kinase perturbation
0.81
histone modification site profile
0.76
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.11   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.11   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0