Protein Summary
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
- ENST00000340057
- ENSP00000344192
- ENSG00000112115
- ENST00000648244
- ENSP00000497968
- CTLA8
- IL17
- IL17
- CTLA8
- IL-17
- CTLA-8
- IL-17A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.8 | ||
chemical | 0.79 | ||
cell type or tissue | 0.76 | ||
gene perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12030.48 (req: < 5)
Gene RIFs: 1556 (req: <= 3)
Antibodies: 1677 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12030.48 (req: >= 5)
Gene RIFs: 1556 (req: > 3)
Antibodies: 1677 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3