You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
JAK1
Tyrosine-protein kinase JAK1

Protein Summary
Description
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342505
  • ENSP00000343204
  • ENSG00000162434

Symbol
  • JAK1A
  • JAK1B
  • JTK3
  • JAK1A
  • JAK1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
protein domain
1
virus perturbation
1
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1227.42   (req: < 5)
Gene RIFs: 222   (req: <= 3)
Antibodies: 565   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1227.42   (req: >= 5)
Gene RIFs: 222   (req: > 3)
Antibodies: 565   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3110
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12