Protein Summary
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]
- ENST00000339987
- ENSP00000342935
- ENSG00000125775
- ENST00000360779
- ENSP00000354013
- ENST00000381808
- ENSP00000371229
- ENST00000381812
- ENSP00000371233
- SITAC18
- ST2
- ST-2
- SITAC
- SITAC18
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
phenotype | 1 | ||
gene perturbation | 0.65 | ||
transcription factor | 0.62 | ||
cell type or tissue | 0.58 | ||
tissue sample | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.42 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.42 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0