Tbio TNNI3 Troponin I, cardiac muscle

Protein Summary

Description

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P19429

Gene Name

• TNNI3

Ensembl ID

• ENST00000344887
• ENSP00000341838
• ENSG00000129991

Symbol

• TNNC1
• CMH7
• RCM1
• cTnI
• CMD2A
• TNNC1
• CMD1FF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
kinase	0.99
biological term	0.94
molecular function	0.73
hub protein	0.71

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Troponin I, Cardiac Muscle

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Troponin I, Cardiac Muscle

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6248.17   (req: < 5)

Gene RIFs: 301   (req: <= 3)

Antibodies: 2305   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6248.17   (req: >= 5)

Gene RIFs: 301   (req: > 3)

Antibodies: 2305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0