Tbio NECAP1 Adaptin ear-binding coat-associated protein 1

Protein Summary

Description

Involved in endocytosis. This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• Q8NC96
• Q2NL73
• Q5XG95
• Q6NWY6
• Q8N153
• Q8NCB0
• Q9BU52
• Q9Y407

Gene Name

• NECAP1

Ensembl ID

• ENST00000339754
• ENSP00000341737
• ENSG00000089818
• ENST00000450991
• ENSP00000401963
• ENST00000639955
• ENSP00000491067

Symbol

• EIEE21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
disease perturbation	0.9
kinase perturbation	0.88
histone modification site profile	0.86
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Adaptin Ear-binding Coat-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0