Tbio HMX2 Homeobox protein HMX2

Protein Summary

Description

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• A2RU54
• B2RNV5

Gene Name

• HMX2

Ensembl ID

• ENST00000339992
• ENSP00000341108
• ENSG00000188816

Symbol

• H6L
• Nkx5-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.67
PubMedID	0.63
biological process	0.6
cell type or tissue	0.6
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.31   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.31   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0