Tclin PKLR Pyruvate kinase PKLR

Protein Summary

Description

Plays a key role in glycolysis. The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30613
• O75758
• P11973

Gene Name

• PKLR

Ensembl ID

• ENST00000342741
• ENSP00000339933
• ENSG00000143627
• ENST00000392414
• ENSP00000376214
• ENST00000571194
• ENSP00000461487
• ENSG00000262785
• ENST00000572740
• ENSP00000459921

Symbol

• PK1
• PKL
• PK1
• PKL
• RPK
• PKRL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.95
biological process	0.94
disease perturbation	0.79
disease	0.73

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Pyruvate Kinase Pklr

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.45   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 487   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.45   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1