PIK3AP1
Phosphoinositide 3-kinase adapter protein 1
Protein Summary
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
- ENST00000339364
- ENSP00000339826
- ENSG00000155629
- ENST00000371109
- ENSP00000360150
- ENST00000371110
- ENSP00000360151
- BCAP
- BCAP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.77 | ||
transcription factor binding site profile | 0.74 | ||
tissue sample | 0.72 | ||
transcription factor perturbation | 0.68 | ||
virus perturbation | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.11 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 305 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.11 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 305 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0