Tbio LRRFIP2 Leucine-rich repeat flightless-interacting protein 2

Protein Summary

Description

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9Y608
• A8K649
• A8MXR0
• B4DY63
• Q68CV3
• Q9NXH5
• LRR FLII-interacting protein 2

Gene Name

• LRRFIP2

Ensembl ID

• ENST00000336686
• ENSP00000338727
• ENSG00000093167
• ENST00000354379
• ENSP00000346349
• ENST00000396428
• ENSP00000379705
• ENST00000421276
• ENSP00000416364
• ENST00000440230
• ENSP00000405480

Symbol

• HUFI-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor perturbation	0.91
transcription factor binding site profile	0.86
histone modification site profile	0.81
transcription factor	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Leucine-rich Repeat Flightless-interacting Protein 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Leucine-rich Repeat Flightless-interacting Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0