Protein Summary
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (Pub ...more
- ENST00000317610
- ENSP00000322147
- ENSG00000115310
- ENST00000337526
- ENSP00000337838
- ENST00000357376
- ENSP00000349944
- ENST00000357732
- ENSP00000350365
- ENST00000394609
- ENSP00000378107
- ENST00000394611
- ENSP00000378109
- ENST00000404909
- ENSP00000385650
- ENST00000405240
- ENSP00000384471
- KIAA0886
- NOGO
- ASY
- NSP
- NOGO
- RTN-X
- NSP-CL
- RTN4-A
- RTN4-C
- RTN4-B1
- RTN4-B2
- NI220/250
- Nbla00271
- Nbla10545
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor binding site profile | 0.99 | ||
co-expressed gene | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1433.89 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 481 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1433.89 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 481 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0