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Tclin
LCK
Tyrosine-protein kinase Lck

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, u ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333070
  • ENSP00000328213
  • ENSG00000182866
  • ENST00000336890
  • ENSP00000337825
  • ENST00000619559
  • ENSP00000477713

Symbol
  • LSK
  • YT16
  • IMD22
  • p56lck
  • pp58lck
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
small molecule
1
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1928.67   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 1561   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1928.67   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 569
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10