Tbio HORMAD2 HORMA domain-containing protein 2

Protein Summary

Description

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

Uniprot Accession IDs

• Q8N7B1
• B5MEB2
• Q8NHR2

Gene Name

• HORMAD2

Ensembl ID

• ENST00000336726
• ENSP00000336984
• ENSG00000176635
• ENST00000403975
• ENSP00000385055

Symbol

• CT46.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.63
disease	0.56
PubMedID	0.51
gene perturbation	0.5
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0