Tclin ADORA2A Adenosine receptor A2a

Protein Summary

Description

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P29274
• B2R7E0

Gene Name

• ADORA2A

Ensembl ID

• ENST00000337539
• ENSP00000336630
• ENSG00000128271
• ENST00000610595
• ENSP00000480012
• ENST00000611543
• ENSP00000483102
• ENST00000618076
• ENSP00000481552

Symbol

• ADORA2
• A2aR
• RDC8
• ADORA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.92
phenotype	0.87
disease	0.84
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adenosine Receptor A2a

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adenosine Receptor / Adenosine Receptor A2a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3064.71   (req: < 5)

Gene RIFs: 325   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3064.71   (req: >= 5)

Gene RIFs: 325   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2239

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7