Tbio SLC51B Organic solute transporter subunit beta

Protein Summary

Description

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.

Uniprot Accession IDs

• Q86UW2
• Q3SYF5
• OST-beta

Gene Name

• SLC51B

Ensembl ID

• ENST00000334287
• ENSP00000335292
• ENSG00000186198

Symbol

• OSTB
• OSTB
• OSTBETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
biological process	0.6
tissue	0.45
cell type or tissue	0.44
chemical	0.43

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc51 Family Of Steroid-derived Molecule Transporters / Organic Solute Transporter Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0