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Tdark
TPGS2
Tubulin polyglutamylase complex subunit 2

Protein Summary
Description
This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334295
  • ENSP00000335144
  • ENSG00000134779
  • ENST00000383056
  • ENSP00000372530
  • ENST00000589049
  • ENSP00000466973
  • ENST00000590842
  • ENSP00000464780
  • ENST00000593035
  • ENSP00000467392

Symbol
  • C18orf10
  • L17
  • PGs2
  • C18orf10
  • HMFN0601
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor perturbation
0.96
histone modification site profile
0.91
kinase perturbation
0.66
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0