Tbio LCE3A Late cornified envelope protein 3A

Protein Summary

Description

A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).

Uniprot Accession IDs

• Q5TA76

Gene Name

• LCE3A

Ensembl ID

• ENST00000335674
• ENSP00000335006
• ENSG00000185962

Symbol

• LEP13
• LEP13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.37
tissue sample	0.37
biological term	0.33
disease	0.32
cell line	0.31

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0