You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
KCNK18
Potassium channel subfamily K member 18

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334549
  • ENSP00000334650
  • ENSG00000186795

Symbol
  • TRESK
  • TRIK
  • TRIK
  • MGR13
  • TRESK
  • TRESK2
  • K2p18.1
  • TRESK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
chemical
0.49
cell type or tissue
0.46
biological term
0.42
cell line
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.47   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.47   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5