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Tbio
SYNE3
Nesprin-3

Protein Summary
Description
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334258
  • ENSP00000334308
  • ENSG00000176438
  • ENST00000553340
  • ENSP00000450774
  • ENST00000557275
  • ENSP00000450562

Symbol
  • C14orf139
  • C14orf49
  • LINC00341
  • KASH3
  • NET53
  • Nesp3
  • C14orf49
  • C14orf139
  • LINC00341
  • NCRNA00341
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
tissue sample
0.61
cell type or tissue
0.58
protein domain
0.58
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.66   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.66   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0