Tchem KDM4D Lysine-specific demethylase 4D

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Uniprot Accession IDs

• Q6B0I6
• B3KPC4
• Q0VF39
• Q9NT41
• Q9NW76

Gene Name

• KDM4D

Ensembl ID

• ENST00000335080
• ENSP00000334181
• ENSG00000186280
• ENST00000536741
• ENSP00000460897
• ENST00000610872
• ENSP00000482224

Symbol

• JHDM3D
• JMJD2D
• JMJD2D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
biological process	0.55
tissue sample	0.54
cell line	0.52
cell type or tissue	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 4d

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 4d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.25   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.25   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0