Tbio MX2 Interferon-induced GTP-binding protein Mx2

Protein Summary

Description

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20592
• B7Z5D3
• D3DSI7

Gene Name

• MX2

Ensembl ID

• ENST00000330714
• ENSP00000333657
• ENSG00000183486

Symbol

• MXB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.97
molecular function	0.91
PubMedID	0.82
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / Hydrolase / Interferon-induced Gtp-binding Protein Mx2

Protein / Enzyme Modulator / G-protein / Small Gtpase / Interferon-induced Gtp-binding Protein Mx2

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Interferon-induced Gtp-binding Protein Mx2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Interferon-induced Gtp-binding Protein Mx2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1122.65   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1122.65   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0