Protein Summary
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
- ENST00000329613
- ENSP00000333114
- ENSG00000182463
- ENST00000371497
- ENSP00000360552
- ENST00000603338
- ENSP00000475114
- C20orf17
- TSH2
- ZNF218
- TSH2
- ZABC2
- ZNF218
- OVC10-2
- C20orf17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
transcription factor perturbation | 0.8 | ||
microRNA | 0.78 | ||
transcription factor | 0.77 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.11 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.11 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0