Tchem SLC8A1 Sodium/calcium exchanger 1

Protein Summary

Description

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• P32418
• A8K6N1
• D6W595
• O95849
• Q4QQG6
• Q587I6
• Q59GN4
• Q9UBL8
• Q9UD55
• Q9UDN1
• Q9UDN2
• Q9UKX6

Gene Name

• SLC8A1

Ensembl ID

• ENST00000332839
• ENSP00000332931
• ENSG00000183023
• ENST00000402441
• ENSP00000385188
• ENST00000403092
• ENSP00000384763
• ENST00000405269
• ENSP00000385535
• ENST00000405901
• ENSP00000385678
• ENST00000406391
• ENSP00000385811
• ENST00000406785
• ENSP00000383886
• ENST00000408028
• ENSP00000384908

Symbol

• CNC
• NCX1
• NCX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
molecular function	0.91
microRNA	0.84
phenotype	0.78
disease	0.76

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc8 Family Of Sodium/calcium Exchangers / Sodium/calcium Exchanger 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 294

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0