Tbio GDF3 Growth/differentiation factor 3

Protein Summary

Description

Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q9NR23
• Q8NEJ4
• GDF-3

Gene Name

• GDF3

Ensembl ID

• ENST00000329913
• ENSP00000331745
• ENSG00000184344

Symbol

• KFS3
• MCOP7
• MCOPCB6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
biological process	0.78
PubMedID	0.74
phenotype	0.6
cell line	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Growth/differentiation Factor 3

DTO Classes

Protein / Signaling / Growth Factor / Growth/differentiation Factor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.44   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 394   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.44   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0