IMMP2L
Mitochondrial inner membrane protease subunit 2
Protein Summary
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
- ENST00000331762
- ENSP00000329553
- ENSG00000184903
- ENST00000405709
- ENSP00000384966
- ENST00000447215
- ENSP00000388327
- ENST00000452895
- ENSP00000399353
- IMP2
- IMP2-LIKE
- IMMP2L-IT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
transcription factor binding site profile | 0.84 | ||
virus perturbation | 0.79 | ||
tissue sample | 0.75 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.05 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.05 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0