Tchem CNGA2 Cyclic nucleotide-gated olfactory channel

Protein Summary

Description

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q16280
• A0AVD0

Gene Name

• CNGA2

Ensembl ID

• ENST00000329903
• ENSP00000328478
• ENSG00000183862

Symbol

• CNCA
• CNCA1
• CNCG2
• CNCA
• CNG2
• CNCA1
• OCNC1
• OCNCa
• OCNCALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.73
ligand (protein)	0.68
gene perturbation	0.62
cell type or tissue	0.59

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Cnga2 Subfamily / Cyclic Nucleotide-gated Olfactory Channel

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.11   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.11   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1