You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WRB
Tail-anchored protein insertion receptor WRB

Protein Summary
Description
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333781
  • ENSP00000327716
  • ENSG00000182093
  • ENST00000380708
  • ENSP00000370084
  • ENST00000398753
  • ENSP00000381737
  • ENST00000649170
  • ENSP00000496813
  • ENST00000650376
  • ENSP00000497103

Symbol
  • CHD5
  • CHD5
  • GET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.76
disease perturbation
0.74
tissue sample
0.72
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0