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Tchem
MYT1
Myelin transcription factor 1

Protein Summary
Description
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328439
  • ENSP00000327465
  • ENSG00000196132
  • ENST00000536311
  • ENSP00000442412
  • ENST00000613234
  • ENSP00000477771
  • ENSG00000276876
  • ENST00000616648
  • ENSP00000483021

Symbol
  • KIAA0835
  • KIAA1050
  • MTF1
  • MYTI
  • PLPB1
  • MTF1
  • MYTI
  • NZF2
  • PLPB1
  • ZC2H2C1
  • ZC2HC4A
  • C20orf36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
cell type or tissue
0.77
gene perturbation
0.76
molecular function
0.7
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1