Tbio FRAS1 Extracellular matrix protein FRAS1

Protein Summary

Description

This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q86XX4
• A2RRR8
• Q86UZ4
• Q8N3U9
• Q8NAU7
• Q96JW7
• Q9H6N9
• Q9P228

Gene Name

• FRAS1

Ensembl ID

• ENST00000325942
• ENSP00000326330
• ENSG00000138759
• ENST00000512123
• ENSP00000422834

Symbol

• KIAA1500
• FRASRS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
histone modification site profile	0.84
PubMedID	0.79
virus perturbation	0.79
transcription factor binding site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.43   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.43   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0