RUFY1
RUN and FYVE domain-containing protein 1
Protein Summary
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- ENST00000319449
- ENSP00000325594
- ENSG00000176783
- ENST00000393438
- ENSP00000377087
- ENST00000437570
- ENSP00000390025
- ENST00000639102
- ENSP00000491803
- ENSG00000284260
- ENST00000639436
- ENSP00000491925
- ENST00000639909
- ENSP00000492748
- RABIP4
- ZFYVE12
- RABIP4
- ZFYVE12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
protein domain | 0.85 | ||
tissue sample | 0.75 | ||
interacting protein | 0.72 | ||
transcription factor binding site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.01 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.01 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0