Tbio CABP4 Calcium-binding protein 4

Protein Summary

Description

Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity). This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P57796
• Q8N4Z2
• Q8WWY5
• CaBP4

Gene Name

• CABP4

Ensembl ID

• ENST00000325656
• ENSP00000324960
• ENSG00000175544
• ENST00000438189
• ENSP00000401555

Symbol

• CRSD
• CSNB2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.66
cell line	0.64
cellular component	0.53
PubMedID	0.53
microRNA	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.16   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.16   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0