You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FLII
Protein flightless-1 homolog

Protein Summary
Description
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327031
  • ENSP00000324573
  • ENSG00000177731
  • ENST00000545457
  • ENSP00000438536
  • ENST00000579294
  • ENSP00000463534
  • ENST00000638207
  • ENSP00000491480
  • ENSG00000284571
  • ENST00000638404
  • ENSP00000492392
  • ENST00000638812
  • ENSP00000491660

Symbol
  • FLIL
  • FLI
  • FLIL
  • Fli1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
disease perturbation
0.97
protein domain
0.92
gene perturbation
0.78
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 720.12   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 720.12   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0