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Tchem
SIGLEC7
Sialic acid-binding Ig-like lectin 7

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305628
  • ENSP00000306757
  • ENSG00000168995
  • ENST00000317643
  • ENSP00000323328
  • ENST00000536156
  • ENSP00000437609
  • ENST00000600577
  • ENSP00000472529

Symbol
  • AIRM1
  • p75
  • QA79
  • AIRM1
  • CD328
  • CDw328
  • D-siglec
  • SIGLEC-7
  • SIGLECP2
  • SIGLEC19P
  • p75/AIRM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.65
kinase perturbation
0.54
small molecule perturbation
0.53
disease perturbation
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.15   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 749   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.15   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 749   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0