PORCN
Protein-serine O-palmitoleoyltransferase porcupine
Protein Summary
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
- ENST00000326194
- ENSP00000322304
- ENSG00000102312
- ENST00000355961
- ENSP00000348233
- ENST00000359882
- ENSP00000352946
- ENST00000361988
- ENSP00000354978
- ENST00000367574
- ENSP00000356546
- ENST00000537758
- ENSP00000446401
- MG61
- PORC
- PPN
- PPN
- DHOF
- FODH
- MG61
- PORC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.87 | ||
kinase perturbation | 0.76 | ||
cellular component | 0.7 | ||
PubMedID | 0.62 | ||
small molecule perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.15 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.15 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 60
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0