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Tbio
ORAI3
Protein orai-3

Protein Summary
Description
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318663
  • ENSP00000322249
  • ENSG00000175938

Symbol
  • TMEM142C
  • TMEM142C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
transcription factor
0.69
histone modification site profile
0.67
tissue sample
0.67
small molecule perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.12   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.12   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0