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Tbio
SLC25A22
Mitochondrial glutamate carrier 1

Protein Summary
Description
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320230
  • ENSP00000322020
  • ENSG00000177542
  • ENST00000531214
  • ENSP00000437236
  • ENST00000628067
  • ENSP00000486058

Symbol
  • GC1
  • GC1
  • GC-1
  • EIEE3
  • NET44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
cell type or tissue
0.75
small molecule perturbation
0.73
transcription factor
0.72
interacting protein
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0