Tbio TACC1 Transforming acidic coiled-coil-containing protein 1

Protein Summary

Description

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Uniprot Accession IDs

• O75410
• B2RBD9
• D3DSX6
• Q6Y687
• Q86YG7
• Q8IUJ2
• Q8IUJ3
• Q8IUJ4
• Q8IZG2
• Q8NEY7
• Q9UPP9

Gene Name

• TACC1

Ensembl ID

• ENST00000276520
• ENSP00000276520
• ENSG00000147526
• ENST00000317827
• ENSP00000321703
• ENST00000518415
• ENSP00000428706
• ENST00000520615
• ENSP00000428450

Symbol

• KIAA1103
• Ga55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
kinase perturbation	0.84
ligand (protein) perturbation	0.83
transcription factor	0.76
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0