Tbio STRBP Spermatid perinuclear RNA-binding protein

Protein Summary

Description

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).

Uniprot Accession IDs

• Q96SI9
• Q32NB9
• Q9BUE1
• Q9BXG4
• Q9H0B4
• Q9H7V1
• Q9NUK4

Gene Name

• STRBP

Ensembl ID

• ENST00000348403
• ENSP00000321347
• ENSG00000165209
• ENST00000360998
• ENSP00000354271
• ENST00000447404
• ENSP00000415968

Symbol

• SPNR
• p74
• SPNR
• ILF3L
• HEL162

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
interacting protein	0.86
kinase perturbation	0.81
microRNA	0.81
cell line	0.69

Protein Classes

PANTHER Classes

Protein / ... / Mrna Processing Factor / Spermatid Perinuclear Rna-binding Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Spermatid Perinuclear Rna-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.32   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.32   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0