Tbio YARS2 Tyrosine--tRNA ligase, mitochondrial

Protein Summary

Description

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9Y2Z4
• D3DUW8
• Q9H817

Gene Name

• YARS2

Ensembl ID

• ENST00000324868
• ENSP00000320658
• ENSG00000139131

Symbol

• TYRRS
• CGI-04
• MLASA2
• MT-TYRRS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
transcription factor binding site profile	0.94
kinase perturbation	0.88
protein domain	0.85
virus perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Tyrosine--trna Ligase, Mitochondrial

Protein / Ligase / Aminoacyl-trna Synthetase / Tyrosine--trna Ligase, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Tyrosine--trna Ligase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.61   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.61   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0