Tbio ELL3 RNA polymerase II elongation factor ELL3

Protein Summary

Description

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).

Uniprot Accession IDs

• Q9HB65
• B3KQ66
• B3KX08
• Q6I9Z7
• Q9H634

Gene Name

• ELL3

Ensembl ID

• ENST00000319359
• ENSP00000320346
• ENSG00000128886

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9
histone modification site profile	0.75
kinase perturbation	0.71
transcription factor binding site profile	0.61
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Rna Polymerase Ii Elongation Factor Ell3

Protein / Cell Junction Protein / Tight Junction / Rna Polymerase Ii Elongation Factor Ell3

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Rna Polymerase Ii Elongation Factor Ell3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0