Tbio GIPC3 PDZ domain-containing protein GIPC3

Protein Summary

Description

Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q8TF64
• O75227

Gene Name

• GIPC3

Ensembl ID

• ENST00000322315
• ENSP00000319254
• ENSG00000179855
• ENST00000644452
• ENSP00000493901

Symbol

• C19orf64
• DFNB15
• DFNB72
• DFNB95
• C19orf64

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.68
tissue sample	0.66
microRNA	0.62
gene perturbation	0.53
tissue	0.49

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Pdz Domain-containing Protein Gipc3

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Pdz Domain-containing Protein Gipc3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0