Tbio NSUN3 tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial

Protein Summary

Description

Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879).

Uniprot Accession IDs

• Q9H649
• Q6PG41
• Q8IXG9
• Q9H6M2

Gene Name

• NSUN3

Ensembl ID

• ENST00000314622
• ENSP00000318986
• ENSG00000178694

Symbol

• MST077
• MSTP077

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor binding site profile	0.75
disease perturbation	0.68
cellular component	0.64
tissue	0.61

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Trna (Cytosine(34)-c(5))-methyltransferase, Mitochondrial

Protein / Nucleic Acid Binding / Trna (Cytosine(34)-c(5))-methyltransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Trna (Cytosine(34)-c(5))-methyltransferase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.92   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.92   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0