Tbio VPS37A Vacuolar protein sorting-associated protein 37A

Protein Summary

Description

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q8NEZ2
• Q336D5
• Q6NW27
• Q8N3D7
• Q8TBL7
• Q96DL9
• hVps37A

Gene Name

• VPS37A

Ensembl ID

• ENST00000324849
• ENSP00000318629
• ENSG00000155975
• ENST00000425020
• ENSP00000412824
• ENST00000521829
• ENSP00000429680

Symbol

• HCRP1
• HCRP1
• PQBP2
• SPG53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
cellular component	0.8
histone modification site profile	0.8
transcription factor binding site profile	0.76
tissue sample	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.89   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.89   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0