Tbio RBBP6 E3 ubiquitin-protein ligase RBBP6

Protein Summary

Description

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z6E9
• Q147T5
• Q15290
• Q6DKH4
• Q6P4C2
• Q6YNC9
• Q7Z6E8
• Q8N0V2
• Q96PH3
• Q9H3I8
• Q9H5M5
• Q9NPX4

Gene Name

• RBBP6

Ensembl ID

• ENST00000319715
• ENSP00000317872
• ENSG00000122257
• ENST00000348022
• ENSP00000316291
• ENST00000381039
• ENSP00000370427
• ENST00000452655
• ENSP00000390537

Symbol

• P2PR
• PACT
• RBQ1
• PACT
• MY038
• P2P-R
• RBQ-1
• SNAMA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.98
transcription factor perturbation	0.96
interacting protein	0.9
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / E3 Ubiquitin-protein Ligase Rbbp6

DTO Classes

Protein / Enzyme / Nuclease / E3 Ubiquitin-protein Ligase Rbbp6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.17   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.17   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0