SH2D3C
SH2 domain-containing protein 3C
Protein Summary
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000314830
- ENSP00000317817
- ENSG00000095370
- ENST00000373276
- ENSP00000362373
- ENST00000373277
- ENSP00000362374
- ENST00000420366
- ENSP00000388536
- ENST00000429553
- ENSP00000394632
- ENST00000629203
- ENSP00000485866
- NSP3
- CHAT
- NSP3
- SHEP1
- PRO34088
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
tissue sample | 0.73 | ||
transcription factor | 0.69 | ||
PubMedID | 0.63 | ||
cell line | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 449.74 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 449.74 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0